Primary HPV testing for cervical cancer screening

For decades the Pap smear was how cervical cancer was caught. Today, primary HPV testing is the recommended test and it allows for self-collection at-home screening.

Primary HPV testing is the most sensitive and efficient cervical cancer screening test available today

Primary HPV testing is recommended by the American Cancer Society5, American College of Obstetrics and Gynecology8, and the U.S. Preventive Services Task Force9

Hands holding an open Teal Health kit box reading 'Welcome to a more comfortable cervical cancer screening.'

High-risk HPV causes nearly all cervical cancer

8 in 10

people will get HPV at some point.1

HPV (human papillomavirus) is the most common sexually transmitted infection, passed through skin contact.

9 in 10

HPV cases clear on their own within two years.2

A healthy immune system handles HPV the same way it handles a cold. The vast majority of infections never cause symptoms or disease.

95%

of cervical cancers are caused by HPV.3

A small number of high-risk HPV types can become persistent. When they do, they’re the cause of nearly all cervical cancer.

THERE ARE 200 TYPES OF HPV

Not all HPV is the same.

The vast majority cause nothing at all. A few cause warts. And 14 — the high-risk types — are the ones screening tests look for.4

Most types

~200 types

Cause no symptoms and clear on their own.

There are roughly 200 types of HPV. Most never cause any health problem and are cleared by your immune system within months to a couple of years.

Low-risk

6 & 11 types

Linked to genital warts — not cancer.

These types can cause genital warts, which are uncomfortable but not cancerous. They’recovered by the HPV vaccine.

High-risk

14 types

The types screening tests look for.

14 high-risk types, including HPV 16 and 18, are linked to cervical cancer. These are the types a primary HPV test detects.

HOW SCREENING GOT HERE

Cervical cancer screening then and now

Cervical cancer screening has gotten better over 80 years. The science kept narrowing in on the actual cause, and the experience is now easier than ever.

1940s

The Pap smear era.

Cervical cancer screening looked for abnormal cells under a microscope. It saved many lives, but it relied on a clinician spotting cellular changes after they’d already started.

2003

HPV testing arrives.

After research showed HPV causes cervical cancer, the first HPV test was approved in the US, running alongside the Pap. The first Primary HPV test was FDA-approved in 2014 (95%+ sensitivity10).

Now

Primary HPV testing — at home.

Primary HPV tests, the recommended test, unlock the ability for women to self-collect their sample without a speculum (>96% relative sensitivity11). In 2025, the first at-home self-collection device, the Teal Wand, is FDA-authorized.

Illustration of the uterus, a fallopian tube and ovary, with a black circle highlighting the cervix at the base.

Three FDA-approved screening tests.

All three modern FDA-approved cervical cancer screening tests are good at finding cancer and pre-cancer.5 The Primary HPV test is the most sensitive, and it’s the one the Teal Wand uses.

Tests for the 14 high-risk HPV types that cause nearly all cervical cancers, catching pre-cancer at the source, before cells change. HPV testing is the only test that allows self-collection.

Test performed with the Teal Wand

REPEAT Self-collect TESTING

Every 3 yrs

Runs both the HPV test and a Pap together. Catches the cause and any cellular changes — can only be done with a speculum exam in a clinical setting.

REPEAT TESTING

Every 5 yrs

Looks under a microscope for abnormal cells that have already started to change — nearly always caused by persistent HPV.

REPEAT TESTING

Every 3 yrs

It was so easy! The instructions were clear and the whole process took less than 5 minutes. Mailing my sample was truly the most complicated part of the process.
Madeleine

29 yrs old

No items found.
If your result is positive

A positive HPV test isn’t a diagnosis— it’s a heads-up.

Here’s what happens next.

01

Take a breath. A positive HPV result is common — and almost always temporary.

Roughly 1 in 8 women who screen will test positive. It does not mean cancer, and it does not mean you did anything wrong.

Common · not cancer

02

Your provider will explain your specific result.

Different high-risk types and reflex Pap results lead to different next steps — sometimes a 12-month retest, sometimes a colposcopy. Your Teal Medical provider walks you through yours.

Personalized follow-up

03

Most people return to a normal screen.

In the majority of cases, the immune system clears the virus within a year or two and the next screen comes back negative. Routine screening is what catches the rare cases that don’t, early enough to prevent cancer.

Why screening works
A close-up shot of a person’s upper arm with a white bandage on their shoulder after receiving a shot, representing preventative care and the HPV vaccine for cervical cancer prevention.
The HPV vaccine

Vaccination + screening = nearly complete prevention.

The HPV vaccine (Gardasil 9) protects against the types responsible for the majority of cervical cancers and genital warts. It works best before exposure, but it can still help later.7

Vaccination doesn’t replace routine screening. The vaccine prevents most, but not all high-risk types, so screening through age 65 is still recommended.

Myth vs. fact

Six things people need to know about HPV

An over-the-shoulder view of a woman unboxing her Teal Health at-home cervical cancer screening kit. The opened box displays the Teal Wand device, a collection vial, a return mailer envelope, and an inside lid reading "Welcome to a more comfortable cervical cancer screening."
Screen on your terms

Cervical cancer screening, at home, in five minutes.

The Teal Wand is the first FDA-authorized at-home self-collection device for cervical cancer screening. It uses the same primary HPV test as the clinic — without the speculum.

FREQUENTLY ASKED QUESTIONS

Answers to questions commonly asked

No. A Pap smear and an HPV test are two different tests that look for two different things. A Pap smear examines cervical cells for abnormal changes. An HPV test looks for the presence of high-risk HPV. Unless your provider specifically ordered an HPV test or a co-test alongside your Pap smear, your routine Pap smear did not test for HPV. If you are unsure which test you received at your last screening, ask your provider or check your results paperwork.

For most people, yes. The Primary HPV test is more sensitive than the Pap smear. It detects the cause of cervical cancer earlier, before cell damage has occurred. The American Cancer Society now recommends Primary HPV testing as the preferred screening method. The Pap smear is still an acceptable option but requires more frequent screening due to its lower sensitivity.

A positive result means high-risk HPV was detected in your sample. It does not mean you have cancer. Most HPV infections clear on their own without causing harm. Your Teal Medical provider will review your result, explain which HPV type was found, and advise on next steps. For many people, the next step is simply monitoring with another screening at a shorter interval.

A co-test runs both a Pap smear and an HPV test on the same sample. It is highly sensitive because it combines both tests, but it also means a higher likelihood of follow-up testing that may not be necessary. A co-test must be performed in-clinic because the Pap smear component requires cells collected from the cervix. The American Cancer Society considers Primary HPV testing alone to be the preferred approach over a co-test for average risk people.

Primary HPV testing is the recommended test by leading medical organizations: American Cancer Society, ACOG, and HRSA. Primary HPV testing detects the virus that causes nearly all cervical cancers before cell damage occurs. Because it catches the underlying cause earlier, it is more sensitive than the Pap smear.

Primary HPV testing is the only cervical cancer screening test that allows for self-collection, enabling more women to get screened.

No. A Pap smear requires cells collected directly from the cervix using a speculum and brush, which must be performed by a clinician in a clinic. At-home self-collection is only available for the Primary HPV test, which collects a vaginal sample rather than a cervical sample. The Teal Wand uses Primary HPV testing for this reason.

Check your results paperwork or contact your provider. If your results mention cytology or cell changes, you had a Pap smear. If they mention HPV or specific HPV types, you had an HPV test. If both are mentioned, you had a co-test. Many people assume they had an HPV test when they actually only had a Pap smear, so it is worth confirming.

The Teal Wand tests your self-collected sample using Primary HPV testing, which checks for 14 types of high-risk HPV. It is the same FDA-approved test used in clinics and the method recommended by the American Cancer Society. It is not a Pap smear. When you screen with the Teal Wand, you are getting the most sensitive cervical cancer screening test available.